Treatment Strategies - Starting Therapy

Treatment Strategies - Starting Therapy  

(See Also: Benefits of HIV Treatment and Risks of Nontreatment


Basic Background Information about HIV Treatment

HIV and Its Treatment.  Fact sheet series from AIDSinfo with an overview of HIV infection and treatment beneficial for individuals recently diagnosed with HIV infection or who are considering starting HIV treatment. Includes information on testing, medications, treatment adherence, pregnancy, and prevention.  Also available in Spanish.

Starting Anti-HIV Medications.  Fact sheet from AIDSinfo for HIV-infected individuals on what to expect when they begin their first anti-HIV treatment regimen.  Also available in Spanish.

Questions to ask your doctor before starting treatment.  Fact sheet from namelife.org. 

Strategies for starting HIV treatment.  Fact sheet from Project Inform.  Also available in Spanish.

U.S. Antiretroviral therapy guidelines. Fact sheet from AIDS InfoNet. Also available in Spanish.

About the HIV Treatment Guidelines.  Fact sheet from AIDSinfo explaining the U.S. Department of Health and Human Services guidelines for the treatment of HIV infection in adults.  Also available in Spanish.

Drug names and manufacturers. Fact sheet from AIDS InfoNet. Also available in Spanish.

Antiretroviral Formulations.  Chart from AIDSinfo listing all available formulations of anti-HIV drugs approved by the Food and Drug Administration for use in the United States.  For each drug, there is a link to an associated fact sheet with information about that specific medication.  Also available in Spanish.
 
Approved Medications to Treat HIV Infection.  Fact sheet from AIDSinfo with a list of medications used to treat HIV infection, including generic and brand names and date approved by the Food and Drug Administration for use in the United States.   For each drug, there is a link to an associated fact sheet with information about that specific medication.  Also available in Spanish.

The rules of the game: Current DHHS treatment guidelines for first time therapy.  Fact sheet and table from the 2011 HIV Drug Guide published by the Test Positively Aware Network.

What is antiviral therapy?  Fact sheet from AIDS InfoNet. Also available in Spanish.

Taking current antiretroviral drugs. Fact sheet from AIDS InfoNet. Also available in Spanish.

Things You Should Know Before Starting Treatment. Fact sheet from aidsmeds.com.

HIV Medication Chart. Chart showing FDA-approved HIV medications. Provided by Community Research Initiative of New England.

Starting antiretroviral treatment.  Fact sheet from avert.org website.

Introduction to HIV and AIDS drug treatment.  Fact sheet from avert.org website.

Strategies for HIV therapy. Fact sheet from Project Inform. Also available in Spanish.

Making decisions about treatment. Fact sheet from Project Inform. Also available in Spanish.

HIV Therapy.  Detailed booklet from namlife.org (PDF file).

Anti-HIV Drugs.  Detailed booklet from namlife.org (PDF file).

HIV+? Start Here. Fact sheet from aidsmeds.com.

First steps to HIV/AIDS treatment.  Web page with links to many resources on thebody.com website.

Personal tracking charts.  Simple charts from Project Inform for tracking T-cell counts, viral load, medications, and other important health information.
 

Selected Articles Related to Starting HIV Treatment

New U.K. HIV Guidelines Cover When to Start ART, Treatment as Prevention, Pregnancy. Article dated February 21, 2012 from hivandhepatitis.com.

Briefly: HIV treatment guidelines updated. Article dated January/February 2012 from Positively Aware.

EACS: Multiple Regimens Are Used for First-Line HIV Treatment, but Outcomes Are Similar. Article dated October 28, 2011 from hivandhepatitis.com.

Cohort Study: No AIDS-Free Survival Benefit to Starting HIV Treatment at CD4s of 500 or More. Article dated October 11, 2011 from aidsmeds.com.

CASCADE Study Finds Benefit of ART Below CD4 Count of 500, But Not Above. Article dated October 7, 2011 from hivandhepatitis.com.

Uncontrolled viral load increases risk of AIDS for patients with a CD4 cell count above 350.  Article dated October 3, 2011 from aidsmap.com.

Older age and immune response to CMV affect CD4 cell recovery after starting HIV therapy. Article dated September 27, 2011 from aidsmap.com.

HIV treatment at 500 CD4 level would put half of patients in need of ART within a year of seroconversion. Article dated September 26, 2011 from aidsmap.com.

Beliefs about efficacy of HIV treatment predict which urban poor patients start antiretroviral therapy. Article dated September 26, 2011 from aidsmap.com.

One in five refusing ART in Soweto, even when in need. Article dated September 22, 2011 from aidsmap.com. 

First-line HIV treatment works just as well in routine care as in clinical trials. Article dated September 13, 2011 from aidsmap.com.

Once-daily etravirine does well in patients starting HIV therapy. Article dated September 7, 2011 from aidsmap.com.

Start Earlier, Say Treatment Guidelines for Children Living With HIV. Article dated August 24, 2011 from aidsmeds.com.

IAS 2011: HIV Treatment In Primary Infection: 48 Week Course Modestly Delays CD4 Drop. Article dated August 12, 2011 from hivandhepatitis.com. 

IAS 2011: Poor CD4 Cell Recovery after Starting HIV Treatment Should Be a Cause For Concern. - Article dated August 9, 2011 from hivandhepatitis.com.

Ready, Set... When? Article dated July/August 2010 from Positively Aware.

To START or not to START? Article dated July/August 2010 from Positively Aware.

IAS 2011: Randomized Trial Supports Earlier Treatment Article dated July 20, 2011 from hivandhepatitis.com. 

Early Treatment Reduces Serious Illnesses by 40% in HPTN 052. Article dated July 19, 2011 from aidsmeds.com.

HPTN 052: early treatment reduces serious illness by 40%. Article dated July 18, 2011 from aidsmap.com.

CD4s Above 500: HIV Treatment Need Still Unclear. Article dated July 6, 2011 from aidsmeds.com.

Only modest benefits from starting HIV therapy with a CD4 cell count above 500 compared to 350. Article dated June 27, 2011 from aidsmap.com.

Tropism impacts on virological success of first-line HIV therapy. Article dated June 8, 2011 from aidsmap.com.

Treatment Is Affected by the T-Cell Coreceptor HIV Uses. Article dated June 8, 2011 from aidsmeds.com.

Older HIV+ People May Benefit from Earlier ART. Article dated June 7, 2011 from hivandhepatitis.com.

First-line treatment for HIV-2: superior outcomes seen with a boosted protease inhibitor.  Article dated May 31, 2011 from aidsmap.com.

HIV Treatment Dramatically Reduces Sexual Transmission.  Article dated May 13, 2011 from hivandhepatitis.com.

ARV Treatment Reduces HIV Transmission 96 Percent.  Article dated May 12, 2011 from aidsmeds.com.

Treatment as prevention works: randomised study shuts 3 years early after showing 96% reduction in risk of transmission.  Article dated May 12, 2011 from aidsmap.com.

More Evidence for Starting ART at 500 CD4 Cells.  Article dated May 6, 2011 from hivandhepatitis.com.

Starting HIV treatment when CD4 cell count dips below 500 improves AIDS-free survival.  Article dated April 21, 2011 from aidsmap.com.

Watch for malnutrition risk in children with HIV after starting ART.  Article dated March 29, 2011 from aidsmap.com.

Immediate ART Improves Survival for HIV+ People with TB.  Article dated March 22, 2011 from hivandhepatitis.com.

Study shows importance of resistance testing before start of HIV treatment. Article dated March 15, 2011 from aidsmap.com.

5 Drugs No Better than 3 for Treatment of Primary HIV Infection. Article dated March 11, 2011 from hivandhepatitis.com.

New Multinational START Trial Explores When to Begin Antiretroviral Therapy. Article dated March 11, 2011 from hivandhepatitis.com.

CROI 2011 Wrap-Up: Taking Research Into Practice. Article and video interview with Dr. Joel Gallant dated March 6, 2011 from The Body Pro website.

Computer Model System Helps Clinicians Select Best Antiretroviral Drug Combo. Article dated February 1, 2011 from hivandhepatitis.com.

U.S. Government Updates HIV Treatment Guidelines. Article dated January 12, 2011 from aidsmeds.com.

Updates to US HIV treatment guidelines. Article dated January 11, 2011 from aidsmap.com.

Immediate HIV treatment has biggest impact in TB patients with CD4 counts below 100. Article dated November 30, 2010 from aidsmap.com.

Things You Should Know Before Starting Treatment. Resource dated November 30, 2010 from aidsmeds.com. Also available in Spanish.

Study confirms that the sooner treatment is started the better.  Article dated November 9, 2010 from aidsmap.com.

News briefs. See section called “San Francisco Adopts Early Treatment” in this article from the Summer/Fall 2010 issue of BETA.

Chronic hepatitis C infection blunts CD4 gains after start of HIV treatment. Article dated August 10, 2010 from aidsmap.com.

Lymphocyte count and haemoglobin can predict prognosis of patients starting ART. Article dated August 3, 2010 from aidsmap.com.

Increased mortality risk for treatment-naive patients with CD4 count below 500. Article dated August 3, 2010 from aidsmap.com.

Ready, set....When?: Debate continues over when to begin treatment. Article from the July/August 2010 issue of Positively Aware.

To START or not to START? Article from the July/August 2010 issue of Positively Aware.

CASCADE analysis finds antiretroviral treatment benefits are evident below CD4 count of 500, uncertain above this level. Article dated July 23, 2010 from aidsmap.com.

Starting ART two weeks after TB treatment reduces death risk by one-third in people with HIV. Article dated July 23, 2010 from aidsmap.com.

Early treatment for infants cheaper than delaying treatment, CHER study shows. Article dated July 22, 2010 from aidsmap.com.

IAC 2010: Possibly No Survival Benefit to Starting HIV Treatment at CD4s of 500 or More. Article dated July 22, 2010 from aidsmeds.com.

CD4 cell count below 500 associated with increased risk of CVD - implications for 'when to start' debate. Article dated July 12, 2010 from aidsmap.com.

Starting HIV Treatment Early Might Reduce Arterial Stiffness.  Article dated June 21, 2010 from aidsmeds.com.

Starting HIV treatment improves immune response to Kaposi's sarcoma.  Article dated June 21, 2010 from aidsmap.com.

Timing of ART initiation during TB treatment may not have significant impact on risk of death.  Article dated June 15, 2010 from aidsmap.com.

Start HIV treatment earlier to reduce risk of hardening of the arteries.  Article dated June 15, 2010 from aidsmap.com.

Majority of HIV patients in North America need to start treatment at time of diagnosis. Article dated May 6, 2010 from aidsmap.com.

San Francisco Endorses Starting HIV Treatment Immediately After Diagnosis. Article dated April 5, 2010 from aidsmeds.com.

The Return of “Hit Hard, Hit Early!” Article from the Spring 2010 issue of Achieve. See pages 12 and 13 of this PDF.

Obese patients in US have poorer CD4 cell gains after starting HIV treatment. Article dated March 22, 2010 from aidsmap.com.

No Benefit From Cyclosporine During Early Infection. Article dated March 18, 2010 from aidsmeds.com.

Immune restoration in DART study: late start means low CD4 count for years. Article dated February 19, 2010 from aidsmap.com.

Treatment for Everyone With HIV?  Article dated December 15, 2009 from aidsmeds.com.

US guidelines now favour treatment at CD4 cell counts between 350 and 500; above 500 not ruled out. Article dated December 1, 2009 from aidsmap.com.

DHHS Guidelines: Return of Hit Hard, Hit Early. Article dated December 1, 2009 from aidsmeds.com.

WHO Guidelines: Treat Earlier, Treat Breast-Feeding Women, Avoid Zerit. Article dated November 30, 2009 from aidsmeds.com.  

Early Treatment, Non-AIDS Disease Management Stressed in New European Guidelines.  Article dated November 17, 2009 from aidsmeds.com.

CD4 cell count below 500 increases cancer risk for patients with HIV.  Article dated October 8, 2009 from aidsmap.com.  

Genital Ulcer Disease Flare-ups in Women Starting HIV Treatment.  Article dated September 29, 2009 from aidsmeds.com.

Flares of genital ulcer disease common in women starting HIV treatment, could temporarily increase infectiousness.  Article dated August 21, 2009 from aidsmap.com.

High Viral Load Patients Equally Fine on Epzicom or Truvada.  Article dated August 7, 2009 from aidsmeds.com.

Abacavir as potent as tenofovir for patients starting HIV treatment with a high viral load.  Article dated August 6, 2009 from aidsmap.com.

More Than Half Could Need Treatment Within 2 Years of Infection.  Article dated July 21, 2009 from aidsmeds.com.

Early HIV Treatment Could Protect Against Brain Dysfunction.  Article dated June 15, 2009 from aidsmeds.com.

HIV treatment should be started earlier in resource-limited settings, shows trial.  Article dated June 12, 2009 from aidsmap.com.

Study Authors Say Treat HIV and OIs at Same Time.  Article dated May 19, 2009 from aidsmeds.com.

When to Start HIV Therapy: Doctors give their opinion on the continuing debate.  Article dated May 2009 from Positively Aware.

Another Study Recommends Earlier ARV Treatment.  Article dated April 13, 2009 from aidsmeds.com. 


When to start treatment: leave it no later than 350, major studies agree.  Article dated April 9, 2009 from aidsmap.com.

Published Study Says Start HIV Treatment as Early as Possible.  Article dated April 2, 2009 from aidsmeds.com.

European study confirms that HIV treatment within three months of birth improves outcome for HIV-positive infants.  Article dated March 11, 2009 from aidsmap.com.

Start HIV Treatment Early But When?  Article dated February 10, 2009 from aidsmeds.com.

When to start HIV treatment: cohort studies disagree on how early.  Article dated February 9, 2009 from aidsmap.com.

Study supports early initiation of HIV treatment by HIV/hepatitis C co-infected patients.  Article dated January 29, 2009 from aidsmap.com.

Earlier HIV Treatment Protects Against Hep C Liver Damage.  Article dated January 26, 2009 from aidsmeds.com.

Immune system defects persist in people who start treatment late.  Article dated January 13, 2009 from aidsmap.com.

Starting HIV Treatment Early Restores Immune Cells to Normal Levels.  Article dated January 7, 2009 from aidsmeds.com.

Starting Therapy Earlier Found to Improve Survival.   Article dated January 2009 from Positively Aware.

Treatment during primary HIV infection has limited benefit.  Article dated November 24, 2008 from aidsmap.com.

Risks Remain for Late Treatment Takers.  Article dated November 21, 2008 from aidsmeds.com.

Evaluating the Costs of Earlier HIV Treatment.  Article dated November 18, 2008 from aidsmeds.com.

Second-line Treatment Fails Twice as Often as First-line.  Article dated November 17, 2008 from aidsmap.com.

Second-line combinations fail twice as often as first-line ones in the first year.  Article dated November 16, 2008 from aidsmap.com.

Changing the HIV Treatment Paradigm.  Article dated November 4, 2008 from aidsmeds.com.

Major Updates to DHHS HIV Treatment Guidelines.  Article dated November 3, 2008 from aidsmeds.com.

Should ARV Treatment Be Started When CD4s Fall Below 500?  Article dated October 27, 2008 from aidsmeds.com.

Start treatment at CD4 cell counts below 500, says large cohort study.  Article dated October 27, 2008 from aidsmap.com.

Is there a role for tropism testing in routine HIV care?  Article dated October 22, 2008 from aidsmap.com.

People Now Able to Stay on First Antiretroviral Regimens Longer. Article dated September 12, 2008 from aidsmeds.com.

 

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